This paper presents a comprehensive review of methods covering significant subjective and objective human stress detection techniques available in the literature. The methods for measuring human stress responses could include subjective questionnaires (developed by psychologists) and objective markers observed using data from wearable and non-wearable sensors. In particular, wearable sensor-based methods commonly use data from electroencephalography, electrocardiogram, galvanic skin response, electromyography, electrodermal activity, heart rate, heart rate variability, and photoplethysmography both individually and in multimodal fusion strategies. Whereas, methods based on non-wearable sensors include strategies such as analyzing pupil dilation and speech, smartphone data, eye movement, body posture, and thermal imaging. Whenever a stressful situation is encountered by an individual, physiological, physical, or behavioral changes are induced which help in coping with the challenge at hand. A wide range of studies has attempted to establish a relationship between these stressful situations and the response of human beings by using different kinds of psychological, physiological, physical, and behavioral measures. Inspired by the lack of availability of a definitive verdict about the relationship of human stress with these different kinds of markers, a detailed survey about human stress detection methods is conducted in this paper. In particular, we explore how stress detection methods can benefit from artificial intelligence utilizing relevant data from various sources. This review will prove to be a reference document that would provide guidelines for future research enabling effective detection of human stress conditions.

Pain in sickle cell disease (SCD) is often associated with increased morbidity, mortality, and high healthcare costs. The standard method for predicting the absence, presence, and intensity of pain has long been self-report. However, medical providers struggle to manage patients based on subjective pain reports correctly and pain medications often lead to further difficulties in patient communication as they may cause sedation and sleepiness. Recent studies have shown that objective physiological measures can predict subjective self-reported pain scores for inpatient visits using machine learning (ML) techniques. In this study, we evaluate the generalizability of ML techniques to data collected from 50 patients over an extended period across three types of hospital visits (i.e., inpatient, outpatient and outpatient evaluation). We compare five classification algorithms for various pain intensity levels at both intra-individual (within each patient) and inter-individual (between patients) level. While all the tested classifiers perform much better than chance, a Decision Tree (DT) model performs best at predicting pain on an 11-point severity scale (from 0-10) with an accuracy of 0.728 at an inter-individual level and 0.653 at an intra-individual level. The accuracy of DT significantly improves to 0.941 on a 2-point rating scale (i.e., no/mild pain: 0-5, severe pain: 6-10) at an intra-individual level. Our experimental results demonstrate that ML techniques can provide an objective and quantitative evaluation of pain intensity levels for all three types of hospital visits.

Advances in sensing and imaging have provided psychology researchers new tools to understand how the brain creates the mind and simultaneously revealed the need for a new paradigm of mind-brain correspondence-- a set of basic theoretical tenets and an overhauled methodology. I develop machine learning methods to overcome three initial technical barriers to application of the new paradigm. I assess candidate solutions to these problems using two test datasets representing different areas of psychology: the first aiming to build more objective Post-Traumatic Stress Disorder(PTSD) diagnostic tools using virtual reality and peripheral physiology, the second aiming to verify theoretical tenets of the new paradigm in a study of basic affect using functional Magnetic Resonance Imaging(fMRI). Specifically I address three technical challenges: assessing performance in small, real datasets through stability; learning from labels of varying quality; and probabilistic representations of dynamical systems.